Behavioral abnormalities were less severe in offspring from the intervention group compared to offspring from the model group, demonstrating that inhibition of NF-κB during pregnancy reduced neurodevelopmental disorders in the offspring.
Employing the asthma model induced by T. canis infection or the ovalbumin-induced asthma model, our group demonstrated that oral treatment with an ethanolic extract of L. pacari decreased the number of eosinophils and neutrophils recruited to BALF [ 73, 74].
Following a very similar model, our group demonstrated that in this setting the relationship between incremental values of leakage and the underestimation of volume shows a linear pattern.
In a parallel study using an ovarian cancer cell line model, our group demonstrated an increased resistance to lovastatin induced G1 arrest in cells overexpressing the LMW isoforms of cyclin E, as compared with cells not expressing these forms, despite the binding of p21 and p27 to these LMW isoforms [ 14].
Using small-molecule and macromolecule model drugs, our group demonstrated that physicochemical properties of the polymers and drugs and structural properties of the matrix can greatly impact drug distribution within microparticles, particle erosion and drug release rates.
Using an elegant mouse model, Even's group demonstrated that MdmX is a better drug target than Mdm2 in lymphoma.
Further, using xenograft animal models, the same research group demonstrated that G-CSF expressing tumours exhibit higher invasive capacity.
Using a mouse model of fungal sepsis, our group demonstrated that IL-7 improved IFN-γ production, decreased apoptosis, and increased survival in mice with Candida sepsis [ 14].
They had every reason to celebrate, what was a normal thing for them was an extraordinary thing to an outsider; the group demonstrated a working model of a cohesive organization that functions effectively with its given diversity.
In addition, in a sheep model of myocardial infarction, the same group demonstrated that myostatin protein is upregulated for up to one month following infarct with a peak occurring at one week.
