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Here we uncover roles for mitochondrial reactive oxygen species (mtROS) during Drosophila dorsal closure, a model for wound healing.
Using an in vitro model for wound healing, we observed that shikonin enhances cell migration of intestinal epithelial cells through a mechanism that involves TGF-β1 induction.
Our present model for wound repair in Dictyostelium cells is depicted in Fig. 8B.
The wound-response signature was derived from an in vitro model for wound healing and can be used to classify tumors as having an 'activated wound-response signature' or a 'quiescent wound-response signature' [ 26, 30].
This analysis requires the use of data from several different sources (higher data dimensionality 98), for example, in a manner similar to that used in validating the model for wound response in the human breast-derived, nontumorigenic MCF10A cell line 99.
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Subcutaneously implanted polyvinyl alcohol (PVA) sponges are extensively used as model for wound-healing studies especially those addressing inflammation [71], [72].
Studies of various wound treatments and products abound, typically sponsored by product companies, however studies addressing health service delivery models for wound care are limited.
Chang et al. analyzed expression profiles of serum-activated fibroblasts as models for wound healing fibroblasts and compared them with profiles obtained from different tumors [ 13].
Falanga, V. et al. Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice.
Unsurprisingly, the dorsal closure during Drosophila morphogenesis shares the same feature and has been extensively studied, which is considered as a powerful model system for wound healing.
This chapter will address different tissue engineering approaches to the reconstruction of either partial or full-thickness living corneal substitutes that can be used either as in vitro models for wound-healing studies, or in vivo, eventually replacing the donor cornea for transplantation in humans.
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