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The presence of multiple tissue types in this organism's small larvae also makes it a potentially important model for toxicological analysis.
In silico prediction model for toxicological effects of ionic liquids (ILs) is useful to understand ILs' toxicological interactions and to design environmentally benign IL structures.
Rodents are becoming the sole model for toxicological experiments.
MSCs have been suggested as a good model for toxicological testing [ 29].
In a recent publication, in vitro and molecular techniques were combined to establish a new in vitro model for toxicological screening (Hrach et al. 2011).
The availability of zebrafish in large numbers, its small size and easy husbandry makes zebrafish a cost-effective model when compared to the rodent model for toxicological studies.
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Furthermore, the transfected HepG2 cells can be co-cultured with fibroblasts such as NIH 3T3 to form liver spheroids that can serve as models for toxicological and pharmacological studies.
Large numbers of chemicals are produced annually and, without efficient models for toxicological testing, the processes of drug discovery and chemical safety evaluation are often delayed.
Expression of GSTs in cell lines selected as models for toxicological studies should be determined and possibility of metabolization of tested compounds should be considered.
The NTP acquired this resource in order to expand our ability to develop predictive models for toxicological effects based on gene signatures, to provide an additional tool for linking in vitro data to in vivo gene signatures and disease outcomes, and to provide additional tissue samples for next generation sequencing based investigations.
C. elegans is an excellent alternative model organism for toxicological screening for several reasons.
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