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Further experiments are needed to validate these findings and create a reliable predictive model for steroid therapy responsiveness.
Midshipman fish are a key model for steroid modulation of reproductive behavior at multiple levels of analysis ranging from behavioral and molecular neuroendocrinology to neurophysiology [ 14, 15].
We used up to seven steroids (including aldosterone, cortisol and 11-deoxycorticosterone [DOC]) to compare the ligand specificity of the ligand binding domains of corticosteroid receptors between a mammal (Mus musculus) and the midshipman fish (Porichthys notatus), a teleost model for steroid regulation of neural and behavioral plasticity.
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The post-emergence death of APRs provides a model for steroid-mediated neuroprotection.
Fourth, reproductive state-dependent variation in eighth nerve encoding of frequency is steroid-dependent [ 13], providing a model for steroid-sensitive hearing variation in humans, in which age-related auditory deficits in post-menopausal woman can be ameliorated with estrogen therapy [ 14].
Therefore, Xenopus oocyte maturation serves as a valuable physiologically relevant model for studying nongenomic steroid signaling (2– 4).
Similar to oocytes, the male germ cells, sperm, also lack transcription and have been used for many decades as a model for transcription-independent steroid signaling.
Thus, we were able to propose and validate a stochastic model of steroid-receptor activity for a reporter gene which provides a new framework for studying this ubiquitous mechanism of eukaryotic gene regulation.
Thus, this model is useful for steroid-induced osteonecrosis studies.
These results did not change after controlling for steroid prescription (model 4).
This association persisted after adjustment for steroid prescription at inclusion (Model 4 in Table 3 and Figure 2).
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