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This distribution is consistent with the previously proposed ramp-threshold model for slippage kinetics [5]: at the time of mitotic entry, level of cyclin B1 starts to decrease (i.e. ramp down) with approximately linear kinetics, until it drops below a threshold that is required to sustain mitotic arrest [7], [9].
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In this work, a novel predictive model for gas slippage factor in micro-porous media with low permeability in the slip flow regime is developed based on the fractal theory.
The finding of repeat sequences in the 3' tail of the HAmo SINEs strengthened the slippage model for initiation of reverse transcription.
The most commonly proposed model for microsatellite mutation is strand slippage during DNA synthesis (Levinson and Gutman 1987).
The importance to account for slippage, transition and diffusion effect in modeling permeability through tight porous media is inferred.
Indeed, the standard slippage model (Levinson and Gutman 1987) requires a single base misalignment for slippage to occur, that is, misalignment of a full repeat is not necessary.
With the potential for slippage obvious, disarming militias is delicate work indeed.
Elston does see a possibility for slippage in enforcement.
Here, monitors of background slippage were defined as nonmicrosatellite loci that nonetheless experience polymerase slippage; however, being smaller than microsatellites, they are not hotspots for slippage.
More importantly, we detected no lower threshold length for slippage.
In the standard DNA slippage model, the slippage probability should be multiplied by the number of sites where slippage can occur (i.e., STR length) leading to a linear relationship between mutation rate and STR length.
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