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Girirajan, S. et al. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay.
Girirajan S, Rosenfeld JA, Cooper GM, et al. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay.
In addition, we asked whether stable expression of desmin could rescue K5 null mice, which served as a model for severe EBS.
We designed a primary neuronal cell model for severe glucose and oxygen deprivation/reoxygenation (OGD/R) to simulate the hypoxic-ischemic condition of patients with severe stroke, trauma, or hypoxic-ischemic encephalopathy.
A secondary aim was to use a locally developed logistic prediction model for severe postoperative bleeding to investigate whether prediction could be improved with inclusion of the variable "surgeon" or selected intraoperative variables.
A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay.
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The improved model and other existing models for severe slugging are tested against a broad range of data.
For the models for severe and disseminated coccidioidomycosis, our numbers were not robust enough to support models with interaction terms.
This onset timing of seizures, loss of body weight and premature death in LGI1−/− mice mirrors that in SCN1A knockout and knock-in mice, which are models for severe myoclonic epilepsy of infancy (Yu et al., 2006; Ogiwara et al., 2007).
Hyperemic velocity was independently associated with sepsis in the multivariable model (OR for severe sepsis per 1 cm/cardiac-cycle decrease in HV = 1.05; 95% CI = 1.02 to 1.08; P = 0.001).
There is a need to model for more severe weather events and climate conditions, especially for those who respond to such events.
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