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However, the high degree of sensitivity of mice to bacterial challenge, especially with the human virulent strains of F. tularensis, limits this animal model for screening of defined attenuated vaccine candidates for protection studies.
The utility of the mouse as a model for screening of lead gamma-secretase inhibitor candidates against Notch endpoints has been previously described [ 41].
In 1997, ZEBET developed an in vitro model for screening of embryotoxicity based on blastocyst-derived embryonic stem cells from mice (mESC).
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This tibia and femur augmentation sheep model proved to be a suitable animal model for screening studies of new biomaterials intended for bone augmentation of trabecular bone and enabled analysis of their biodegradable, biocompatible and osteoconductive properties.
Currently there are no recommended models for screening for individuals at high risk of dementia.
To validate hESC-atrial CMs as a preclinical model for screening the selectivity of ion channel blockers, we tested the effects of antiarrhythmic agent, vernakalant (Wettwer et al, 2013).
In an organ culture model for screening agents capable of inhibiting human saphenous vein intimal hyperplasia, leoligin showed a profound inhibitory activity.
The models also allow for screening of potential new therapeutic approaches that can then be translated to the clinical setting for further evaluation and study.
Hence, stimulation of macrophages with LPS offers an excellent model for screening and subsequent evaluation of the inflammatory effects of candidate drugs.
Therefore, this model can be used for screening of the cyclic nitrogen injection process for a well with hydraulic fractures, when the quantities of specified operational and reservoir/hydraulic fracture parameters are provided.
Since multiple-stress generates what appears to be truly dormant Mtb cells similar to those found in vivo, this in vitro dormancy model might be suitable for screening of drug candidates that can kill dormant Mtb.
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