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It is an open question whether or not a renewal process is an appropriate model for recombination.
The approach here is to specify a model for recombination and derive multilocus probabilities directly from that model.
The renewal crossover process is a model for recombination in diploid individuals that involves two strands - maternal and paternal haploids.
Building on studies in fungi, in 1964 Robin Holliday proposed a model for recombination in meiosis which introduced key details of how the process can work, including the exchange of material between chromosomes through Holliday junctions.
We used the recombination model (-MR0 option), the general model for recombination rate variation in Li and Stephens (2003).
These IBS regions are assessed for significance empirically, conditional on a model for LD and a genetic model (for recombination in the pedigree).
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Section 5 reviews our findings and makes some general comments about the plausibility of renewal models for recombination.
Better models for recombination, even if not exactly correct, may help detect disease or trait loci and build genetic maps.
Some models for recombination in E. coli depict RecBCD as preferentially degrading the 5'-ending strand after an encounter with Chi [8], [61], [62].
This creates an apparent contradiction since all the standard cleavage-ligation independent models for recombination, such as SDSA, do not lead to crossing over.
Several models for recombination depict only 3' ends invading a homologous duplex, which predicts the formation of 3' patches only (Figure 1A and C, and [6] [8], [61], [62]).
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