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As a model for proof of concept, we used enfuvirtide, an antiretroviral fusion-inhibitor peptide approved for treatment of human immunodeficiency virus (HIV) infection.
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These findings do not support the potential usefulness of this panic model for proof-of-concept studies.
As a previous report could demonstrate that caspase-2 is a critical caspase in the apoptosis of HeLa cells induced by pore-forming toxins, we chose this model for proof-of-principle experiments.
This novel isolation of equine cord blood MSCs and their preliminary in vitro differentiation positions the horse as the ideal pre-clinical animal model for proof-of-principle studies of cord blood derived MSCs.
Repeated low-dose LPS challenges potentially result in a small shift of the neutrophil/monocyte ratio; however, the cumulative response is reproducible, enabling the use of this model for "proof-of-concept" studies for anti-inflammatory compounds during early drug development.
The adult beta globin gene was selected as the model gene for proof of concept of autoimmunity as a biocontrol method for cane toads.
The pan-caspase inhibitor z-VAD.fmk is a prototype compound that has been used extensively in vitro and in animal models for proof-of-concept studies.
We used the guinea pig model for a proof of concept study and took advantage of the fact that in outbred Dunkin Hartley Guinea pigs, BCG vaccination resulted in a significantly delayed onset of symptoms and prolonged survival after infection.
Although we have taken PfGyrB as a model for the proof of mechanism of action of ACF, it can be extended to other DNA binding proteins.
UNICEF has also provided seven prefabricated offices for the Ministry of Education and is working with the Ministry and partners on a model for earthquake proof schools using innovative building technologies, including environmentally friendly compressed earth blocks.
Therefore this novel line may provide a useful additional model for establishing proof-of-concept for new therapeutic concepts.
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