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The Decision Analytic Model for Oral Pre-cancerous Lesions.
This study established a basic in vitro single and mixed-species culture model for oral bacteria combining three complimentary methods.
4NQO-induced lesions appear to be a good model for oral cavity carcinogenesis [ 14].
A Golden Syrian hamster model for oral precancer was utilized in this study [ 30].
There were six variables in the final model for oral cancer in women.
Certainly, further research has to be done in order to integrate a predictive model for oral health services utilization.
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The pharmacokinetic parameters were determined using WinNonlin Professional, version 5.0.1 (Pharsight, CA, USA), and by noncompartmental modeling using software model 200 for oral dosing and model 201 for intravenous dosing.
Then, seven machine learning approaches were used to establish the QSAR models for oral acute toxicity.
A sensitivity analysis, which included those participants without laboratory evidence of HHV-8 infection by either HHV-8 seropositivity, HHV-8 DNA detection from mucosal surfaces or blood, or biopsy proven KS, did not change the results of multivariate models for oral HHV-8 detection or viremia (data not shown).
Thus, we used the same strategy to assess the validity of models for oral drug absorption.
Given all of these facts, more examples of evaluated pediatric PBPK models for oral drugs are still in demand.
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