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To analyze the effects of the compounds, we used the PC12 cell line, a widely used neuron-like cell culture model for neuronal differentiation studies [ 44].
A linear model for neuronal activity, namely f i ( v i ) = − l v i with l a positive constant.
Neuro2a is a mouse neural crest-derived cell line that has been widely used as an experimental model for neuronal differentiation study.
The leaky integrate-and-fire model for neuronal spiking events driven by a periodic stimulus is studied by using the Fokker Planck formulation.
The retinotectal projection has become a prime example of a retinotopic organisation and is widely used as a model for neuronal pathfinding in developmental biology (e.g. [34]).
In summary, we provide evidence of two different kinds of neurite terminals in PC12 cells, including a PC12-specific terminal, which implies that care must be taken when using them as a model for neuronal growth cones or neurite outgrowth.
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Our results suggest that investigators should be cautious when extrapolating data obtained in PC12 as models for neuronal growth cones.
As one of the most extensively studied models for neuronal differentiation, PC12 cells respond to a broad spectrum of pharmacological agents, which trigger a myriad of intracellular signaling pathways leading to neuronal differentiation.
DCM simultaneously optimizes model parameters for neuronal interactions (between region connectivity) and the regionally specific hemodynamic forward model (neurovascular coupling).
Morphine biosynthesis was recently shown in the SH-SY5Y human neuronal catecholamine-producing cell line [8], [9], a well-known model for studying neuronal secretion [11], [12].
The kainic acid-induced selective neuronal damage in rat hippocampus [23] has been a commonly-used in vivo model for excitotoxic neuronal damage [24].
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