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A number of theoretical and experimental studies support this model for mitochondrial movement.
In the MPA algorithm, we introduced a transient model for mitochondrial movement and transient velocity analysis.
Introducing donor mtDNA could lead to subtle problems in offspring that haven't yet been studied in the only primate model for mitochondrial replacement: macaques.
Based on these findings, we propose a modified model for mitochondrial network formation.
The Mitochondrial disease group was also strongly represented among Ho16 downregulated genes (p = 5.25 × 10-03) and included among others technical knockout, a model for mitochondrial disease [ 40].
tko 25t has been considered as a model for mitochondrial diseases, exhibiting not only seizures and developmental delay but also hearing impairment (Toivonen et al. 2001).
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Several molecular models for mitochondrial (mt) gene rearrangements have been proposed, but observational evidence has been insufficient to evaluate them.
One of the earliest animal models for mitochondrial diseases was a Drosophila melanogaster with a technical knockout (TKO) of the gene encoding the mitochondrial ribosomal protein S12.
With regard to the latter, novel mitochondrial gene replacement methodologies in stem cells may aid with the developing animal models for mitochondrial diseases in the future.
Conversely, other studies found the opposite trend, with younger estimated ages when using complex codon partitioning models for mitochondrial data (e.g., Nearctic and eastern Palaearctic skinks [ 23]).
Given a scarcity of transgenic models for mitochondrial disorders chemically induced models, based on the specific and irreversible complex I inhibitor rotenone, have been used in studies of PD, AD and LHON.
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