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A honeycomb-like molecular structure model for mechanistic explanation of ALA was postulated and discussed.
After a comprehensive characterization of the co-culture model, translocation studies were performed with four widely used model substances/drugs (sodium fluorescein (Na-F), FITC-dextran, indomethacin, antipyrine) as well as with 50 and 70 nm PS NPs to showcase the value of the model for mechanistic studies on NP translocation across the individual layers as well as the co-culture barrier.
Although mice constitute the most convenient and versatile model for mechanistic immunological research (plethora of genetically engineered strains and immunological reagents), the tiny size of the murine oral cavity has presented technical challenges for ligature placement.
The Nrf2−/− mice can provide a novel model for mechanistic and translational research on AMD.
Syrian hamster embryo cells are a relevant model for mechanistic studies of chemical carcinogenicity.
The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic investigation.
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Zarcone, D., Tilden, A.B., Friedman, H.M. & Grossi, C.E. Human leukemia-derived cell lines and clones as models for mechanistic analysis of natural killer cell-mediated cytotoxicity.
The field lacks of spontaneous and translatable models for mechanistic investigations.
The field lacks of spontaneous and translatable models for mechanistic studies.
There are several reports on fed-batch enzymatic saccharification which mainly deal with the development of appropriate kinetic models for mechanistic description of the phenomena [ 9, 12, 13].
The underlying mechanisms, however, remain only partially characterized, and there is an increasing need to establish effective animal models for mechanistic studies and drug screening.
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