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Recently, Luo's laboratory developed a novel Akt activator (SC79) which augments neuronal survival in mouse model for ischemic stroke [ 35].
In an immune suppressed rat model for ischemic cardiomyopathy, human MSC from aged donors performed worse [ 22].
Together, these results reveal that RGMa interaction with Neogenin promotes survival in an in vitro model for ischemic insult.
The mean ± SE coefficient for our logarithm model for ischemic heart disease was 0.3031 ± 0.0152 for the standard Cox survival model and 0.2894 ± 0.0440 for the random-effects survival model.
The commonly used in vitro model for ischemic stroke involves oxygen-glucose deprivation and rodent model for stroke involves mechanical or thromboembolic occlusion of cerebral vessel to mimic cerebral ischemia.
In this study we demonstrate that the up-regulation of apelin expression causes exuberant endothelial cell proliferation and pathological angiogenesis in the retinas of mice with oxygen-induced retinopathy (OIR) [ 13], a frequently used model for ischemic retinal diseases [ 14].
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Using rodent models for ischemic stroke (MCAo), we have shown that miRNAs are temporally regulated during progression/reperfusion of cerebral ischemia and miRNAs in total blood could be used as diagnostic markers.
Additional file Table 3 shows the results of the multilevel Poisson regression models for ischemic heart disease in women.
Furthermore, application of recalibrated Framingham models for ischemic cardiovascular disease (including ischemic stroke and coronary events) significantly overestimated the CHD risk in another Chinese cardiovascular epidemiology cohort [ 16].
Although endothelial dysfunction might be present in many of the current animal models for ischemic diseases, the specific role of oxidative stress on therapeutic outcomes has rarely been explored owing to the confounding effects of different co-morbidities.
Backward variable elimination, with an elimination criterion of a P-value of more than 0.05, was then used to create a parsimonious model for predicting ischemic stroke.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com