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Primary human colonic cultures provide an in vitro model for interrogating the human enteroendocrine system, and co-secrete GLP-1 and PYY.
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These include to what extent the models truly recapitulate basic aspects of the human disease, to what extent they can be used as models for interrogating genomic changes, and how they can be most effectively used to identify new drug targets across a wider range of disease types.
Model systems are ideal for interrogating metabolic questions in a tissue dependent context.
Animal models provide experimentally tractable systems for interrogating NDD, however, not all animal models faithfully mimic human pathophysiology.
Advancement of genetically engineered mouse models has provided new tools for interrogating these mechanisms.
However, a mammalian Lmod3 mutant model will be a valuable resource for interrogating the underlying pathogenesis of NM and for the development of therapeutics.
Therefore, a mammalian Lmod3 mutant model will be a valuable resource for interrogating the underlying pathogenesis of NM and developing therapeutics.
This model could be a valuable resource for interrogating myopathy pathogenesis and developing therapeutics for NM as well as other pathophysiological conditions with preferential atrophy of fast fibers, including cancer cachexia and sarcopenia.
Complex cellular processes can be described and studied with computational or mathematical models., When these models are driven by biological data, they provide reliable platforms for interrogating cell systems in silico.
Finally, in the evolving paradigm of molecular imaging, in vivo bioluminescence imaging (BLI) has evolved as a very attractive tool for interrogating human cellular biology in rodent models.
As a model experimental species, the ferret has emerged as particularly useful for investigating acoustically driven behaviors and for interrogating the underlying brain structures and physiological processes.
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