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Open image in new window Fig. 13 a Matrix water saturation and b the pressure regime both introduced into the model for initiation.
We propose that the PTRE-HPRT system presented in this study represents a valid model for initiation and progression of aberrant silencing in cancer because silenced PTRE-HPRT alleles display the hallmarks of tumor suppressor gene silencing (promoter region DNA methylation, histone hypoacetylation, loss of methyl-K4 H3, and gain of methyl-K9 H3).
The finding of repeat sequences in the 3' tail of the HAmo SINEs strengthened the slippage model for initiation of reverse transcription.
On the limited number of promoters tested in this study, TBP and TBP2 could replace each other depending on their relative expression levels, providing an experimental model for initiation factor switching.
Although we adjusted our model for initiation of antiretroviral use, we did not have data on compliance with regimens, length of time patients were treated, adverse reactions, or development of resistance.
Low-dose tumor risks predicted by a quadratic model for initiation diverged at low dose from those predicted by low-dose-linear models and were about 100-fold smaller at an exposure to 1 fiber per milliliter of air, even though the models provided similar fits to the data.
Similar(54)
Future models for initiation of RRT should include nonrenal indicators for outcome.
Tables 3, 4 and 5 show ORs and 95% CIs from multivariable-adjusted models for initiation, discontinuation and continuous use of the five most commonly used supplements after breast cancer diagnosis, among women who were and were not using the specific supplement prior to diagnosis, respectively.
A mouse model for liver initiation and promotion involved initiation by injection of N-nitrosodiethylamine (DEN) intraperitoneally into male B6C3F1 mice at 4 weeks of age, followed by exposure to either DEHP in the diet (3000, 6000, or 12,000 ppm) or phenobarbital in the drinking water (500 ppm), beginning 1 to 2 weeks later and continuing for periods of from 1 day to 18 months.
We develop a numerical model for the initiation and growth of an array of parallel radial hydraulic fractures.
A mechanistic model for crack initiation is modified to capture the influence of pre-exposure on life.
Related(20)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com