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In order to be able to compare the anti-inflammatory activity of soy isoflavonoid genistein, which has already been confirmed by previous studies [9 11], to the one of genistein incorporated in HPBCD and RAMEB, inflammation was induced using the mouse ear model for inflammation and ear thickness was measured.
The mouse lung is a well-studied model for inflammation and infection.
Second, the localized damage induced in the superficial neuromasts could be used as a model for inflammation mediated by infection.
To investigate the hypothesis that Pebisut reduces inflammation by modifying cell function, we used the TG-induced peritonitis model for inflammation.
After the statistical selection of p parameters by minimizing the Akaike Information Criterion AICC), we can easily determine whether the regulatory TFs candidate is a significant or just a false positive and then construct a refined gene regulatory network model for inflammation.
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We chose mesothelial cell injury as a model for inflammation-induced tissue injury because mesothelial cell loss is a clinical problem in PD.
The traditional model for inflammation-mediated fetal demise is injection with Toll-like receptor agonists such as poly(I C) or lipopolysaccharide.
Additionally, in a dual disease animal model both for inflammation and prostate cancer, it could be shown that [F]-FACBC targets human prostate cancer and could separate cancer from inflammation [ 8].
Several mouse models for inflammation-related colorectal cancer have been developed, including dextran sodium sulphate (DSS) –induced colitis models and genetically engineered models.
In order to study neutrophil-mediated formation of carcinogenic N-nitroso compounds as a mechanism of inflammation-related colon carcinogenesis, we designed an in vitro model for intestinal inflammation, consisting of a coincubation system with human colon cells (Caco-2 cells) and activated human neutrophils (PMN), as important immunoreactive cells.
As a model for chronic inflammation, the study included patients suffering from RA who indeed showed a higher level of inflammation compared to OA patients as indicated by CRP, ESR and number of leucocytes.
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