The semiphysiological model was based on the base population PK model and a separately developed mixed-effect model for gestation-induced change in CrCL.
The minimum adequate model for mean gestation duration included male mass, which was significantly negatively associated mean gestation duration (Table 2).
Under the traditional approach, logistic regression models for early gestation fetal, neonatal or perinatal death included only live births and fetal deaths at 22 33 weeks.
The exposures were administered for 2 weeks before mating, during pregnancy, and through postnatal day 10 a model for the human gestation period.
Model I then adjusts for family history of asthma; model II additionally adjusts for gestation, parity, maternal education, breastfeeding, and the amount the mother smoked during pregnancy; model III additionally adjusts for paternal smoking in pregnancy and exposure of the child to environmental tobacco smoke at two time points.
DRI, Disability Rating Index; P4 test, Posterior Pain Provocation test; HSCL-25, Hopkins Symptom Check List In the multivariable model for pain intensity in gestation week 30 similar results were found (table 5).
The best-fitting models for both SBP and DBP had 3 knots at 18, 30, and 36 weeks' gestation, and the model for weight had 2 knots at 18 and 28 weeks' gestation.
Linear models for length of gestation were adjusted for maternal race, age, employment status and infant sex.
The final models for length of gestation included continuous variables for maternal age, week prenatal care was initiated, and dimethyl phosphate in urine at 26 weeks, as well as categorical variables for parity, mother's country of birth, family income, and smoking.
