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Most recently he has concentrated his laboratory research on the pathophysiology of ATP1A3 dysfunction in the brain as model for epilepsy and of Alternating Hemiplegia of Childhood.
We have showed that GAT-2/3 mediated GABA release does not contribute to the [GABA]o under normal, physiological conditions, but significantly emerges in low-[Mg2+] medium which is a standard in vitro model for epilepsy [24], [42], [43].
The best fitting model for epilepsy was that which included deprivation score only (p = 0.770).
There are many advantages of the kindling model for epilepsy research.
One family with ATP6AP2 mutation was reported to have epilepsy, hence, we tested the mouse model for epilepsy susceptibility.
By June 2006, 3323 communes were covered by this project (13) and in 2009, the management model for epilepsy and depression had been implemented in 53 communes (i).
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These tools exemplify a concerted research agenda, shared methodological principles and models for epilepsy self-management, and a communal knowledge base for implementing e-Health to improve quality of life for people with epilepsy.
These observations indicate that LGI1 knockout mice could provide two distinct animal models for epilepsy: heterozygous mice recapitulate the genetic cause and mimic the human condition with an auditory epileptogenic trigger, while homozygous mice are interesting due to an early onset of spontaneous seizures with a probable origin in the temporal lobe structures.
We evaluated the efficacy of vagus nerve stimulation (VNS) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a validated model for absence epilepsy.
The study is based on genetic interactions that modify phenotypes in para bss1, a model for intractable epilepsy (p arker et al. 2011a).
Here we examine a Drosophila model for intractable epilepsy, the Na+ channel gain-of-function mutant para bss1 that resembles Dravet syndrome in some aspects (p arker et al. 2011a).
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