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In conclusion, not only do functional anisotropic hESC-VCMs engineered by multi-scale topography represent a more accurate model for efficacious drug discovery and development as well as arrhythmogenicity screening (of pharmacological and genetic factors), but our approach may also lead to future transplantable prototypes with improved efficacy and safety against arrhythmias.
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Presented in this study is an efficacious model for the in vitro isolation of tumorspheres, containing breast tumor-initiating cells, from human breast core biopsies.
Previous studies have examined the effects of vIL-10 in the AIA rabbit model as well as the collagen induced arthritis mouse model showing efficacious results for treatment [ 11, 12, 32, 33].
The Bypassing the Blues study found this model efficacious for reducing depression in patients undergoing coronary artery bypass grafting surgery [ 31].
This realisation has engendered an intense search for efficacious chemopreventive intervention strategies using animal models of premalignant and malignant colorectal cancer.
Equine F (ab') 2 fragments specific for H5N1 have been used for efficacious prophylaxis and therapy in a mouse model [8].
We suggest that naturally occurring sepsis in the dog represents the ideal model for defining diagnostic biomarkers and discovering efficacious therapeutics for use in human sepsis.
Blocking of this metabolic hot spot led to discovery of 10 (CKD533) which is highly potent, selective and orally efficacious in conscious rabbit model for erectile dysfunction and now is undergoing preclinical toxicology study.
Also, because of uncertain parameters of the model, an efficacious possibilistic robust optimization approach was applied.
The disinfection method proposed here shows the potential for efficacious application to this species.
Also, because of the uncertain parameters of the model, an efficacious possibilistic robust optimization approach is utilized.
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CEO of Professional Science Editing for Scientists @ prosciediting.com