It also provides a causative model for common ear malformations and is potentially the key to a developmental pathway for pinna morphogenesis that underlies these disorders.
Taken together, our results support the implementation of Xenopus as a viable model for inner ear research, especially for investigation of hair cell regeneration, morphogenesis, and organogenesis.
We have used the embryos of the frog Xenopus laevis as an animal model for early ear development to examine the effects of different EYA1 mutations.
The model for the ear emergence day was also very accurate and gave high weight to putrescine and tryptophan (Additional file 3, Table 1).
Moreover, amphibians (along with birds and fish) have been shown to regenerate or transdifferentiate hair cells after trauma and therefore are a useful model for inner ear research [ 13, 14, 32].
In order to be able to compare the anti-inflammatory activity of soy isoflavonoid genistein, which has already been confirmed by previous studies [9 11], to the one of genistein incorporated in HPBCD and RAMEB, inflammation was induced using the mouse ear model for inflammation and ear thickness was measured.
These are almost the "bargain basement" model for Ultimate Ears but they're quite comfortable and you still get excellent -26db noise isolation an, because I've worn these for so long, I think the comfort has grown on me.
A real-life model for the ears would greatly help you if you're having a hard time envisioning exactly how you want your ears to look, and if no one's around/willing to help you, Google Images can always provide a photo or two.
Because Ush1g is a scaffold protein, the presence of three Ush1g genes in fish may affect the fish "USH interactome" (and consequently eye and inner-ear development) differently than in humans; such differences should be considered when using fish systems as general models for vertebrate ear physiology.
(He's got Miles Davis running all through his music, but he's not booked at jazz festivals in the United States; he tends to play progressive-minded European festivals, including Punkt in Norway, one of Mr. Capps's models for Big Ears).
