Your English writing platform
Discover LudwigSuggestions(2)
Exact(1)
In an effort to elucidate the cellular mechanisms that establish the switch of dormant to rapidly growing cells, Almog et al. [ 75] designed an in vivo model for dormancy of various cancers, including OS, and performed gene-expression analysis of cells in the dormant state versus cells in a proliferative state.
Similar(59)
Using tamoxifen-induced mammary quiescence as an in vivo model for tumour dormancy, we identified several candidate stromal mediators of tumour quiescence.
This model is entirely consistent with the clinical model of dormancy proposed by Demicheli (see Figure 4 in [ 7]).
Landsberg (1974) proposed the parallel model for identifying the dormancy characteristics of apple buds, indicating that regardless of temperatures, the phenological expression of plants is affected.
An identical overlap exists between the gene expression profiles of Mtb cells treated with NO or CO, and when cultured under low O2 conditions (Wayne model for in vitro dormancy) (Refs 9, 144, 145, 146).
An unexpected finding in the anaerobic model for in vitro dormancy was that the Mtb NAD+ and NADH levels were only approximately 50% of the aerobic levels when O2 was consumed, whereas the NAD+/NADH ratio was similar to that in aerobic conditions (Ref. 60).
This is the first report of an in vitro multiple-stress dormancy model for Mtb that manifests all features characteristic of in vivo dormancy and implicate a critical link between storage lipid accumulation and drug-tolerance.
Recently, Deb et al. developed a multistress dormancy model for M. tuberculosis and showed that M. tuberculosis exhibited all the hallmarks characteristics of dormancy [ 59].
In vitro models of dormancy have identified hypoxia, nitric oxide (NO) and nutrient starvation as dormancy inducing signals [4] [6].
We also have discussed concepts of tumour dormancy derived from pre-clinical research models of dormancy in breast cancer.
Discovery of effective drugs against non-replicating tubercle bacilli requires appropriate in vitro models of dormancy.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com