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Inclusion of covariates explained some of the random IIV of the population parameters in the final model for CL and V1.
Continuous covariate effects can be introduced into the population model using a variety of functions, including a linear function: This function constitutes a nested model against a base model for CL because θ2 can be estimated as 0, reducing the covariate model to the base model.
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Major improvements were achieved for NOx by the long-term flow-anomaly model and for Cl by the ADF (average discounted flow) model and the short-term flow-anomaly model.
The two-compartment model was parameterized for CL, V1, V2, and Q. Models using a full omega variance−covariance block matrix on all structural parameters or a diagonal variance structure on all or some parameters did not result in acceptable convergence.
Comparison results showed that the ensemble approach (SVR +ANN) and SVR were the best models for predicting CL and HL, respectively, with mean absolute percentage errors below 4%.
This aspect is understudied in human VL although several reports are available in murine models for both CL and VL.
2 Therefore, we developed an economic model of CL with and without HIV co-infection to quantify the impact of HIV co-infection on CL infection and a second model to help establish a TPP for a new CL treatment, accounting for HIV co-infection.
Currently, important limitations of the standard primary hepatocyte model for prediction of CL appear to be negative bias and high phenotypical variability, as discussed.
These include successful modelling of halogen interactions for Cl, Br and I, which each display the so-called "sigma hole" in QM calculations, and likewise interactions between sulphur and oxygen.
Chan et al. proposed a modified version of the CL model for fast staircase reduction in denoising problems [9].
We present Monte Carlo simulations using an equilibrium lattice-gas model for the electrosorption of Cl on Ag(1 0 0) single-crystal surfaces.
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