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Cook, P. R. & Marenduzzo, D. Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations.
Lei, M., Podell, E. R. & Cech, T. R. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Most of our studies have focused on the fruit fly Drosophila melanogaster as a model for chromosome function in metazoans, which allows us to address mechanisms in animals by synergistically combining molecular, genetic, cell biological and biochemical approaches.
According to our results we propose and discuss a comprehensive model for chromosome structure in meiosis.
Generally, the incorporation of these geometrical constraints into a theoretical model for chromosome configurations is non-trivial.
In the submitted article, Muscat et al. present a new model for chromosome segregation in female meiosis.
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The translation model for chromosomes to gene-protein networks and the gene-network dynamic system model is detailed later, preceding sections describing the way the cellular dynamics are translated into organism and cellular functionality.
There has also been pronounced progress in analysing chromosome structural data, producing structural models for chromosome folding32,33.
The first chromosome-engineered mouse model for human chromosome 15q11-13 duplication fulfills not only face validity of human autistic phenotypes but also construct validity based on human chromosome abnormality.
Ultimately, the ability to target particles to different parts of the cell nucleus may start to impact on models available for chromosome aberration formation and chromosomal organisation and mechanisms underlying genomic instability.
PhastCons was then run in rho-estimation mode on each of the zebrafish chromosomal alignments to obtain a conserved model for each chromosome.
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