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Based on the differences we observed between MSS and MSI tumors, a putative model for carcinogenesis was proposed.
However, atherosclerosis has been an insufficient model for carcinogenesis.
These fundamental principles are well illustrated by the rodent liver model for carcinogenesis.
We used normal rat kidney tissue, which is a suitable model for carcinogenesis due to oxidative stress.
Experimental data seems to be consistent with the progression model for carcinogenesis from the benign precursor to ovarian cancer but they could not be unequivocally replicated.
As mentioned above, the multistep model for carcinogenesis states that many of these properties are 'acquired' during tumour evolution (Loeb, 1991; Hahn and Weinberg, 2002).
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A laboratory approach is reviewed which includes: development and study of whole animal models for carcinogenesis, analysis of animal tissue responses to carcinogens in vivo and through in vitro culture methods for morphological and biochemical studies, and development of in vitro culture methods for human target tissues.
Recently such resources have been developed for important aquaculture species including rainbow trout, which are also widely used as a model system for carcinogenesis, toxicological, and comparative immunological research [ 1].
In conclusion, we propose for the first time a model of carcinogenesis for metastatic NB based on dictionary learning.
If further studies corroborate the important role of Capn3 in urothelial tumors of the urinary bladder, cattle with urinary tumors may prove useful as animal model for bladder carcinogenesis.
Recently, a dualistic model for ovarian carcinogenesis has been suggested.
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