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We used a knockout mouse model for adipose triglyceride lipase (ATGL) to study the dependence of mitochondrial acetylation dynamics on fatty acid oxidation in the liver, heart, brain, and brown adipose tissues of fed and fasted mice.
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The zebrafish (Danio rerio) has recently emerged as a new model system for adipose tissue research, in which WAT can be imaged in a transparent living vertebrate at all life stages.
Here, we have eight set of genes (each set for each model) for skeletal and adipose SA tissue.
While chickens have been used heavily for studies of developmental biology and immunology, a number of traits make them a viable model for studies of adipose biology, obesity and insulin resistance.
In addition, our results indicate that different decision tree methods and workflows can be used for Vss prediction and we have shown an example of a model developed using Kt:p for adipose tissue.
Due to their profound fat loss, morbidly obese patients undergoing bariatric surgery represent a powerful model for studying changes in adipose tissue biology.
In addition, in a recent study proposing a physiologically-based pharmacokinetic model for improving the prediction of tissue distribution and volume distribution of highly lipophilic compounds [19], the simulation of the partition coefficient for adipose tissue was considered more sensitive to lipophilicity, by comparison with a non-adipose tissue.
Most recent models of appetite regulation have drawn attention to the roles for adipose tissue and GI peptides.
Overall, we can conclude that these cell lines are a reliable model for in vitro studies of different adipose tissue depots and are a powerful tool for future drug discovery studies.
Detailed in vitro and in vivo studies on the stereoselectivity of ATGL, HSL and DGAT2 (DAG-acyltransferase 2) suggested a 'three-pool' model for cellular DAGs in mouse white adipose tissue [ 85].
In a matched case control study from Costa Rica, the lipophilic index for adipose tissue was significantly positively associated with myocardial infarction in multivariable adjusted models [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com