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The first model is more accurate however it demands an offline model fitting step.
The results of the model fitting step performed with PMM-Lab are shown in Tables 2 and 3. Overall, most of the fitted models had an R greater than 0.94 with a few exceptions (minimum was 0.915).
In practice, the grid model fitting using multi-site data is more complicated than what is described in this manuscript (we focused on the model fitting step).
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One at a time, all covariates excluded from the initial model fits (steps 2 and 3) are re-tested to confirm they are neither statistically significant (p ≤ 0.05) or a confounder.
Diggle et al 6 and Lawson 40 have suggested fitting step function models, which include a plateau of constant elevated risk up to an unknown distance δ, and models allowing for angular direction from a point source.
In other words, each model fitted at step 2 expanded the multivariable Cox's PH model built at step 1 by estimating and testing time-dependent and non-linear effects of a single predictor.
The three stages are: data acquisition using relay feedback; non-parametric identification of the system step response; and parametric model fitting of the identified step response.
Several methods can be used to identify a nonlinear viscoelastic model, but given that the QLV and AQLV models are capable of fitting step-wise elongations (admittedly with a fairly large number of parameters), we decided to modify these models to also fit the saccadic and constant-speed elongations.
Randomly sample the time from LTFU to death in each patient lost to follow-up, based on the model fitted in step 1, with the hazard of death increased by factor HRLTFU.
The differences between the -2log likelihoods of this model and the two-parameter model fitted in step (c) was tested using a χ2 test.
In the case of GBW, taking into account both direct and maternal additive effects improved the model fitting in the second step.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com