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The difference between the model fits is an unbiased estimate of the level of optimism derived from the model fitting process.

Detailed description of the models, fitting procedures, numerical methods, and statistical analysis of the model fits is presented in the Supporting Material.

First, because this list of SNPs has been filtered for D'[ 45] values, the risk of over-counting in our statistical model fits is reduced.

Although the low orthology percentage alone could not exclude the "duplication and divergence" model, taken together with differences on GC3-content and codon usage bias, the possibility that this model fits is minimal.

A graphical illustration of the temporal timelines of the epidemic, as illustrated by the three model fits, is given in Figure 6.

Moreover, an illustrative comparison of the estimates for R as obtained by the model fits is also provided in Figure 7.

The model fitted is log-linear in duration of EPT.

Two other aspects of the model fitting are important.

Total fitting scores (goodness of the model fitting) were GFI = .979, CFI = .979, RMSEA = .039.039

The thermodynamic data derived from the model fitting were summarized in Table 1.

Previous model fitting was based on Ft values >2 corresponding to fevers >104°F [17].