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Independent of its cholesterol-lowering effects, simvastatin attenuated vasa vasorum neovascularization in a pig model fed a high cholesterol diet [ 57].
In this study, we examined the effects of W-LHIT, a natural product developed by our laboratory based on TCM, on HFD-induced obese mice using a previously employed C57BL/6 J murine model fed a 45% kcal HFD [ 26].
The basis for these intestinal motility changes is unknown, but might relate to the excess biliary cholesterol excreted into the duodenum and/or the hypercholesterolemic state of the animal model fed a high cholesterol diet.
T. Kurita-Ochiai and M. Yamamoto examined the role of P. gingivalis or A. actinomycetemcomitans in augmenting inflammatory mechanisms and oxidative modification in the formation and activation of atherosclerotic plaques in ApoE-deficient mouse model fed a high-fat diet.
Recently, microarray and bioinformatics analyses, performed to reveal the specific miRNAs profile responsible for transition from steatosis to steatohepatitis in a rat model fed a fat-rich diet, showed the dysregulation of miR-199a during the progression of liver inflammation from steatosis, in which it is downregulated to steatohepatitis in which it is upregulated instead [ 102].
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Alzheimer transgenic models fed a HFD show exacerbated memory impairment as well as increased levels of Aβ oligomers and deposition [ 87, 88].
EPA and DHA help prevent obesity and insulin resistance particularly in animal models fed a high-fat diet [ 85, 86], but effects in humans have yet to be proven.
These findings are comparable to what has previously been observed in mouse models fed a low protein diet, where reductions in the branched chain amino acids were also observed (Eckert et al., 2012).
Based on these findings, other studies proposed new animal models fed an atherogenic diet with high levels of cholesterol and cholate, which could both lead to atherosclerosis and NASH.
Additionally, these results clearly demonstrate the necessity to confirm the behavioral phenotype of a mouse model fed with a 15N diet.
Finally, the experimental determinations of the growth rates are compared to the prediction of a low-order acoustic model fed with a Flame Transfer Function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com