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The model features pulsatile pressure and flow, a source impedance and compliant vessels including bifurcations.
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The applicability of this model to pulsatile flow conditions was verified using an in vitro flow circuit.
When temporal periodicity was introduced as a model of pulsatile flow, the net luminal flow served as an index of flow-mediated spatio-temporal tissue drug uptake.
Sankar and Lee [20] have developed a two-fluid model for pulsatile blood flow through arterial stenosis treating the fluid in the core region as Herschel-Bulkley fluid.
Additionally, we found that in a preclinical model, a pulsatile high-dose schedule of lapatinib was superior to standard daily dosing.
Since no version of the Guyton model captures pulsatile mechanics, no version of the model can capture the baroreceptor resetting phenomena illustrated in Figures 2 and 3 of our paper.
As a model system of pulsatile drug release, dibucaine hydrochloride and κ-carrageenan hydrogel were chosen as a drug and a device, respectively.
Our objective is to model three different pulsatile signals concentration, all having the same total molecular concentration.
Understanding the response of single neuron models to pulsatile stimuli is considered next in the paper by Castejón et al. [3].
Human cancer xenograft models comparing pulsatile to continuous administration of gefitinib in combination with paclitaxel demonstrated superior tumour kill with the pulsatile schedule (Solit et al, 2003).
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