Sentence examples for model expressing human from inspiring English sources
To clarify the role of adipocyte-derived SAA, a transgenic mouse model expressing human SAA1 (hSAA) in adipocytes was established.
An AD mouse model expressing human amyloid precursor protein (hAPP) with Swedish and Indiana mutations [ 55].
Here we followed the fate of single dendritic spines in the neocortex of a tauopathy mouse model, expressing human P301S mutated tau, for a period of two weeks.
P McLaughlin (Groningen, the Netherlands) investigated the consequences of targeting monoclonal antibodies to normal and tumour tissue in a transgenic murine model expressing human EpCAM.
Our report identified several autophagy genes as strong modifiers of neurodegeneration using an in vivo model expressing human MAPT in Drosophila.
Recently, a transgenic mouse model expressing human APP with the 714 austrian mutation has been reported showing intraneuronal Aβ accumulation correlating with brain atrophy [ 65].
Several drug administration protocols have failed in providing long-term beneficial effects11 and our group was the first to provide in-vivo insights of syndrome neurobiology using Caenorhabditis elegans to generate knockin models expressing human mutated DAT from patients displaying either "typical" DTDS or "atypical" form of the syndrome15.
In this study, to test this hypothesis of non-cell autonomous effects by glial cells as well as by stem/progenitor cells, we generated and analyzed phenotypes of Drosophila models expressing human mutant Htt or Atx1 in the glial cell lineage at different stages of differentiation.
Drosophila models expressing human Ataxin-3 proteins have provided novel insights into SCA3 disease (10– 10).
The apoE isoforms strongly influence amyloid deposition in the human brain (apoE4 > noncarriers) and in amyloid precursor protein (APP) mouse models expressing human apoE isoforms (apoE4 > apoE3 > apoE2).
Elevated p38 activity is found in brains from patients with tauopathies (145– 147) and in transgenic AD mice models expressing human tau (148– 150) or mutant APP (151), both of which correlate with tau aggregation.
