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In our model exposure of trigeminal ganglia cell culture to IL-1β led directly to delayed CGRP release from TGN 24 hours after stimulation with an earlier non-significant trend after 10 hours.
In this model, exposure of F0 dams resulted in abnormal pulmonary function, as well as altered expression of the remodeling marker fibronectin in F3.
In the first described brain HP model, exposure of neonatal rats to 3 hours of 8% oxygen almost completely protected against hypoxia-ischemia induced infarction [ 3].
In our model, exposure of both PPHN and control pulmonary arteries to serum during organ culture induced cell cycle progression, and this was increased in the presence of exogenous thromboxane; this models the effect of loss of endothelial integrity.
In an isolated perfused rat heart model, exposure of myocardial tissue to acetate concentrations as low as 5 mmol/L resulted in impaired fatty acid oxidation and decreased ATP turnover [ 16].
In a rat model, exposure of pregnant dams to vinclozolin and methoxychlor (endocrine disruptors) during the period of gonadal sex differentiation in the fetus led to decreased spermatogenic capacity in the male offspring and an increased susceptibility to adult-onset diseases and hypercholesterolemia in the F1 to F4 generations [ 83, 84].
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(5) It is noteworthy that only one study has attempted to model exposures of the population further back in time than the 1980s.
In many of these models, exposure of the nasal respiratory system to an airborne agent is the first step in the pathway leading to symptoms.
Model 1: exposures of main interest adjusted for smoking status Model 2: exposure of main interest adjusted for smoking status, maternal country of birth, maternal BMI, maternal education.
In planning for long-duration spaceflight, it will be important to accurately model the exposure of astronauts to heavy ions in the galactic cosmic rays (GCR).
To address these questions, we devised a novel model of exposure of young mice to ambient particulate matter (PM) and ovalbumin (OVA) as the sensitizing antigen, followed by chronic inhalational challenge with a low mass concentration of antigen.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com