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Considering the indecomposable FSMC model, evolution of channel is taken as a stationary Markov process.
We described a system that makes it possible to model evolution of primitive but functional cells.
In order to simplify analysis of the model, evolution of suicide is considered first in the absence of adaptive immunity.
The continuous modeling approach uses coupled ordinary differential equations (ODEs) to model evolution of gene expression over time (Chen et al., 2004; Goodwin, 1963; Li et al., 2008).
The model, originally devised in [ 24] to model evolution of unstable gene amplification and then analyzed mathematically by other, is presented in Fig. 1b.
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Modelling evolution of regulatory sequences can be useful for understanding both the general mechanisms of gene expression control and the regulatory history of particular genes.
This was achieved using the implementation of Continuous in the BayesTraits package which models evolution of continuous traits on a phylogeny using a generalized least-squares approach under Brownian motion model of evolution.
This method is embedded in a Bayesian framework and models evolution of codons to explain both observed intraspecific polymorphism and interspecific divergence.
I explicitly state that the punctuated equilibrium model is probably the prevailing model of evolution of multicellular species in the corrected version of the manuscript.
This is well illustrated for example in the "Toolbox model of evolution of prokaryotic metabolic networks and their regulation" by Maslov et al. [ 35], see below.
We model the evolution of a heterogeneous prostate cell population using a continuous state-transition model.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com