compartment in the local model for each compartment addressed in the kinetic law (this can be the compartment of a participating species or the reaction itself can have a compartment assigned to it).
These data were then used for deriving the distribution of ventilation and blood flow in a 50-compartment lung model, with each compartment having a specific alveolar ventilation/blood flow ratio (VA/Q ratio) ranging from zero to infinity.
The organ retention function is the solution of the model in each compartment; the organ doses are directly related to the integral of radioactivity of Zr in source organs over 50 years.
The residual variability was described with proportional error models for each compartment.
The amino acid composition of the reference model protein for each compartment was calculated by taking the sum of the compositions of each model protein for a compartment in proportion to its fractional abundance in the total model protein population of the compartment.
Model fitting to the premature infant data was obtained by adjusting the adult model parameters of each compartment that directly exchanges FDG with the plasma.
The model parameters for each compartment i used for the matching include threshold opening pressure TOP i, stiffness coefficient S i and extrinsic pressure P ext,i, meaning that a total of 300 model parameters are considered for 100 compartments in the simulator.
A key distinction between the two models is that in the maturation model all protein molecules entering the Golgi together will exit at the same time, while in the vesicular transport model, mixing in each compartment facilitates different protein molecules residing in each compartment for different lengths of time.
Specifically, we average the posterior probability each model estimates for each compartment, for each protein and also report the standard deviation.
This search yielded a number of model proteins for each compartment, ranging from 5 (ER to Golgi) to 746 (cytoplasm); see Table 3.
The relative abundances of model proteins for each compartment inferred from experimental data were found in some cases to correlate with the predicted abundances, and both positive and negative correlations were found for some assemblages of proteins in known complexes.
