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A folate-targeted, DNA-based nanoparticle was also recently tested in a murine tumor model, displaying an elimination half-life (24.2 min) and kidney uptake similar to our non-encapsulated DNO, suggesting it may have suffered from a comparable, rapid degradation profile after injection.
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An additional transgenic model displaying a pro-aging phenotype had a BRCA1 mutation that constitutively activates p53 via the enhanced endogenous DNA damage signals [ 9].
To the best of our knowledge this represents the first mammalian transgenic model displaying a defect in mitotic chromosome condensation and is also the first mouse model for impaired Mcph1-function.
It is apparent that an in vitro cellular model displaying a gene expression profile similar to that observed in vivo varies with both the gene and the tumour.
Our results are another indication that the role of SR-BI in lipoprotein metabolism and atherogenesis in rabbits – a CETP-expressing animal model displaying a manlike lipoprotein profile may be different from the one found in rodents.
IOMA is shown to successfully predict changes in fluxes both in E.coli's central metabolism under various genetic perturbations and in a simulated RBC kinetic model, displaying a significant improvement versus the commonly used FBA and MOMA methods.
The dispersion curve of the wave-guide model displays an acoustical radiation scheme which differs significantly from that of a thin homogeneous plate.
Relative to the base model, the final model displayed an OFV reduction of 34.11.
It is noteworthy that the EP model displays an opposite direction phase-shift, implying distinct dynamic transitions in the adjustment of the system.
As shown in Fig S5, a 5-miRNA model displayed an AUC of 0.77 when applied to the testing set.
Indeed, hypertrophied cardiomyocytes in the rat 6-week-stenosis model displayed an increase in phosphorylated CREB levels.
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CEO of Professional Science Editing for Scientists @ prosciediting.com