To the best of our knowledge this represents the first mammalian transgenic model displaying a defect in mitotic chromosome condensation and is also the first mouse model for impaired Mcph1-function.
It is apparent that an in vitro cellular model displaying a gene expression profile similar to that observed in vivo varies with both the gene and the tumour.
An additional transgenic model displaying a pro-aging phenotype had a BRCA1 mutation that constitutively activates p53 via the enhanced endogenous DNA damage signals [ 9].
Our results are another indication that the role of SR-BI in lipoprotein metabolism and atherogenesis in rabbits – a CETP-expressing animal model displaying a manlike lipoprotein profile may be different from the one found in rodents.
IOMA is shown to successfully predict changes in fluxes both in E.coli's central metabolism under various genetic perturbations and in a simulated RBC kinetic model, displaying a significant improvement versus the commonly used FBA and MOMA methods.
Previous work has shown that in another mouse model displaying a reduced AMPK activity, in which LKB1 was expressed at only approximately 10% of the normal levels in most tissues, these animals were viable and displayed no overt phenotypes or marked glucose intolerance [ 34, 56].
