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Although homology analysis showed low sequence similarities between the MDA5 TFIIS domain and the C4 type zinc finger nucleotide binding motif within the human TFIIS central domain, 3D modelling displayed significant structural similarities (Fig. 6).

No significant difference in mechanical thresholds was detected between the normal and sham model group (P>0.05), as shown in Figure 2A and B. Animals in the model group displayed significant allodynia to mechanical stimulation in both the hind paw and the abdomen (P<0.05).

In the glucose-loaded hyperglycemias model, SCEE displayed significant antihyperglycemic action.

The homology derived model of Sebox3 displayed significant conservation of the GGD /E EF architecture as well.

In an HCT-116 nude mice xenograft model, compound 1o displayed significant antitumor activity in both continuous and intermittent dosing schedules.

The basic model displayed a significant coefficient for all attributes included.

None of the other variables included into the univariate model displayed a significant influence on BMFS (Table 2).

The final model displayed a significant association with indeterminate clinical form (β = 2.599), proportion of homes with running water (β = -2.334) and presence of a decentralised health care unit (β = 0.524).

The mouse xenograft model of HCC827-AR1 cells displayed significant ALDH1 expression, although the parental HCC827 cell line did not exhibit ALDH1 expression by immunohistochemical staining (Fig. 3c).

All three in vitro models treated with Imetelstat displayed significant reduction of telomerase activity throughout treatment (Fig.  2d f), as well as progressive telomere shortening compared to control cells (Fig.  2g i).

In the murine air pouch granuloma model, ACRH and QRF both displayed significant and dose-dependent anti-inflammatory effects, without granuloma weight.