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The use of such measures to model disease progression in NPIs may be problematic, as such interventions often not only focus on slowing progression of the disease, but also on independence of patients and quality of life (both patients' and caregivers') such as those assessed in Martikainen [29].
Ultimately, this will allow researchers to better model disease progression, and of course the effect of any drug on the body.
A sub-study will model disease progression in a smaller cohort.
Thus, efficacy data (FEV1) from the tiotropium arm of the UPLIFT trial were used to model disease progression in both the tiotropium and the glycopyrronium cohorts.
In the model, disease progression subsequent to a diagnosis of diabetes was simulated based on data primarily obtained from the UK Prospective Diabetes Study UKPDSS) (23).
Because in this trial the primary outcome measures, such as the BSI, are continuous measures, it will not be possible to create an unambiguous definition of health states to model disease progression.
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In many types of decision models, disease progression is directed by progression probabilities, i.e. the probability of shifting from one health state to another.
13 The function f(t) models disease progression.
Models for time to event provide the link between standard pharmacokinetic dynamic models disease progression, and clinical outcome events.
Weaknesses have been identified with this methodology in modeling disease progression, obtaining good quality information on costs for patients treated in the community, and sensitivity to small changes in estimated incremental costs.
In addition to standard SNP-based association studies, ADNI genetics data have also been used in several other applications, including in a comparative study of genotype imputation (Nho et al. 2011), copy number variation analyses (Swaminathan et al. 2011, 2012a, b), and for modeling disease progression (Samtani et al. 2012).
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model disease surveillance
model steatosis progression
model disease pathogenesis
model disease risk
model disease activity
model disease gene
model disease deterioration
model order progression
model disease duration
model disease process
model disease biology
model tumour progression
model tumor progression
model disease state
model disease pterygium
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