Our shRNAi model disclosed TOPK, a kinase involved in cell proliferation and motility, as a new target of EWS FLI1.
A linear mixed model disclosed that rise of PEEPtotL was explained by PP for an amount of 2.7 (SD 0.44) cmH2O and by thorax angulation for 0.13 (SD 0.02) cmH2O per degree (p < 10−6).
However, using a dose-response pharmacodynamic model authors disclosed a significant nonlinear dose-response relationship between dopamine agonists and frequency of ICD symptoms [ 31].
Warner's business model, disclosed in the due-diligence process, was strikingly optimistic.
The Broken plus Intact Cells model disclosed kinetic and structural differences between the three biomass samples (natural, ground and dewaxed leaves), being able to explain the distinct trends of the various removal curves.
Multivariable analysis by Cox's proportional hazard model disclosed S-NSE as the most powerful prognostic factor followed by poor PS and extensive stage disease.
As this is still to be developed, specific details on decision logic and model building will be published subsequently, with full transparency of analyses used to develop the model disclosed at that time.
Multivariate analysis using the Cox proportional hazards model disclosed two significant independent prognostic factors on disease-specific survival, the nodal involvement (risk ratio: 8.4; P < 0.0001) and the extent of lymph node dissection (risk ratio: 5.8; P < 0.005).
+, decoration of microtubules; -, no decoration of microtubules The screening, by means of DS Visualizer program, of tyrosine residues exposed in A. thaliana microtubule model disclosed that only tyrosines 426 and 437 out of the 16 tyrosine residues present in consensus sequence of all β-tubulin isotypes were completely exposed on the outer side of microtubule surface.
Meanwhile, this modeling disclosed that a more suitable optimization strategy might be to modify the benzene ring at 3-position of furanone with hydrophilic groups.
