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Priors and posteriors for the fitted model are shown in Supplementary Figs S3 S4, and model diagnostics are plotted in Supplementary Figs S5 S8.

Model diagnostics are available [ 14].

Model diagnostics are implemented in EBSeq-HMM to ensure that assumptions can be easily checked.

We will only attempt this analysis if the results of the investigation of heterogeneity do not rule it out and the model diagnostics are acceptable.

We intend to only attempt this analysis if the results of the investigation of heterogeneity do not rule it out and the model diagnostics are acceptable.

Model diagnostics are provided in Supplementary Materials and Methods online (Supplementary Figures S1 – S3 online) and normalized visual predictive checks are shown in Supplementary Figure S4 online.

Model diagnostics were performed and found acceptable.

Model diagnostics were evaluated using the Hosmer and Lemeshow statistic.

The residual and model diagnostics were within acceptable limits [ 15].

Standard model diagnostics were investigated including normality and homoscedasticity of residuals.

Model diagnostics were performed to check regression assumptions and assess the influence of possible outlying data.