The Lived Experiences model, a human-based model of developmental processes leading to shared intentionality, was applied successfully to chimpanzees.
Recently, the ability to derive iPSCs from terminally differentiated human cells was a groundbreaking discovery, with alluring potential for cell-specific disease models, regenerative medicine, modeling physiological developmental processes and drug discovery (Wu and Hochedlinger, 2011).
Despite these, popular models of morphogen gradient formation [15], [18], [22] and mathematical models of developmental processes [23], [24] usually include a diffusive mechanism for morphogen transport.
In recent years, mathematical modelling of developmental processes has earned new respect.
These approaches allow for more refined mutagenesis screens that will greatly accelerate functional mouse genomics and generate mammalian models for developmental processes and cancer.
We seek candidateswhose research focuses on the use of systems-level technologies (e.g., advanced imaging methods, whole-genome analysis, computational modeling) tounderstand developmental processes (e.g. live imaging of cell migration, gene activity)in either invertebrates or vertebrates.
We believe that reaction diffusion models explaining developmental processes in multicellular organisms may be tested and emulated in artificial, tissue-like arrangements of cell-mimics even when they are composed of unnatural materials, operate on different scales and with different molecular mechanisms.
Conceptually, at the centre of the model lies the regulation of WUS via two separable feedback operated reaction-diffusion systems, a commonly used type of differential equation models for developmental processes in biology [22].
We propose a physical model for developmental process at cellular level to discuss the mechanism of epigenetic landscape.
In this article we provide a review of lifespan developmental models, describe normal developmental processes that affect pain processing, and identify deviations from those processes that lead to stable individual differences of clinical interest, specifically the development of chronic pain syndromes.
