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23 To take the interindividual variability into account, model development was performed using nonlinear mixed effects modeling, and the software NONMEM (version 7.3 by ICON Development Solutions, Ellicott City, MD) with the ADVAN 13 subroutine was used.
The model development was based on the database that was previously used to develop stand-alone models for ACR20 (ref. 15) and ACR50 (ref. 10) responses; however, this new approach has the advantage of gaining more information from the same amount of data, as various levels of response are characterized simultaneously.
Model development was a multi-step process.
The developmental research phase I: model development was employed.
The model development was made in two steps: calibration and validation.
The model development was largely based on the data contained in the Swedish database.
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The model development is presented in Section 2.
The history of model development is briefly outlined.
Finally, future directions in the HINT model development are proposed.
Full details of the model development are given in this study.
The next step after the model development is to run it.
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