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Towards model development, a novel oral inhibitor of PHD2 developed at Pfizer Corporation (Cambridge, MA), henceforth referred to as PHI-1, was utilized to obtain the time-course data on relevant pharmacokinetic-pharmacodynamic (PK-PD) endpoints at time scales ranging from hours to weeks.
As a first step of model development a simulation model of control rod drive mechanism (CRDM) has been developed using SIMULINK®.
Based on this model development, a new H∞ control strategy is proposed to yield improved tracking performance and disturbance rejection.
In the model development, a porous medium is divided into the mobile and immobile regions to consider the presence of ineffective micropores in physically heterogeneous riverbanks.
In parallel with the model development, a series of experiments using a mobile gamma camera apparatus have been performed for direct measurement of the radial distributions of velocity and solids density which occur in a cold-flow riser.
As part of a broader effort to provide detailed measurements of turbulent flames in dual-mode scramjets, promote a deeper understanding of the relevant combustion physics, and aid appropriate computational model development, a high-subsonic cavity-stabilized premixed ethylene air flame (typical of ramjet operation) is studied using coherent anti-Stokes Raman spectroscopy.
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During the early phases of model development, an exact mapping might not be available to modellers.
A comparison of three techniques for rapid model development: an application in patient risk-stratification.
Testbenches are an integral part of model development and a significant portion of the total effort.
This paper describes the three step model development of a masonry retrofit and window system under external blast loading.
Model development was a multi-step process.
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