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The correlations (Table 2) and structural equation model described were based on these factor scores.

Potential uses of the model described were: as a tool for GP trainees and educators; as a teaching aid for undergraduate medical students; for analysing the demand management pathway when commissioning; for comparing what was being commissioned with what was evidence based; and to direct research into poorly evidenced areas.

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The model described is estimated using the British Household Panel Survey (BHPS).

While the model described is at an early stage, efforts for improving the model sensitivity to other factors that cause epigenetic changes are in progress.

The models described are monogenic (a single autosomal locus).

However, discrete-time models described are more reasonable than the continuous-time models when populations have nonoverlapping generations.

The models that we describe are generative models, also known as directed acyclic graphical models [34].

The model described above is represented in Fig. 1.

The results with all models described above were qualitatively similar.

Again, the two extreme models described above were used.

The two-part models described previously are mixture models at the observation level.

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