The current studies were designed to distinguish between the two distinct topological models currently proposed for HIV-1 gp41 by determining the accessibility of key CTT sequences in the context of virions and Env-expressing cells to binding by reference MAbs.
Models currently proposed in the literature include reduced disease-mediating cytoadherence of parasitized hemoglobinopathic erythrocytes, impaired intraerythrocytic development of the parasite, dampened inflammatory responses, or a combination thereof.
Although the radiation model as currently proposed has no free parameters and is attractive in its simplicity, it is not yet clear to what degree previously proposed gravity-like mobility kernels can achieve similar or better fits to observed patterns by estimating two or three key parameters.
The forecast model differs from currently proposed models by its assumption of non-stationarity and its density estimation technique.
This forecast model differs from currently proposed models by its density estimation and its assumption of temporal changes.
Our model differs from currently proposed models by its density estimation technique and by the inclusion of potential temporal changes, often ignored, within the Gutenberg Richter distribution.
That being said, the currently proposed model performs as well as or outperforms other models that are proposed in the literature.
The predictions from the currently proposed model were compared with available experimental data, as well as with predictions of an earlier unit cell-based model, and a good agreement was obtained.
A currently proposed model is that LRRK2 kinase activity could potentiate a trans-acting kinase activity or repress a phosphatase activity toward the upstream kinase phosphosites.
The observed results are consistent with the currently proposed model of telomere regulation, based on experiments in genetically modified cells, which has demonstrated that TRF2, TRF1, TIN2, and POT1 are each negative regulators of telomere length.
