The models constitute two nested pairs (M1a + M2a and M7 + M8) with one model of each pair only containing site classes allowing dN/dS to vary between 0 and 1 (neutral models; M1a and M7), while the second model of each pair (selection models; M2a and M8) contains an additional site class in which dN/dS ≥ 1, thus allowing positive selection.
On the other hand, we favor the hypothesis that KSHV tumorigenesis is the culmination of multiple complex interactions between the virus and its host, and lytic replication as a driver of clonal evolution and systems dysfunction, as outlined in our model, constitutes but one aspect of this dynamic and complex process.
Extraction of the MFs and design of the MF-based model constitute our two main contributions.
Here we present the data obtained by the use of a model constituted of two cell types: the alveolar type II cell line, NCI-H441 and the human pulmonary microvascular endothelial immortalised cells, HPMEC-ST1.6R.
Basically Frank's model constitutes a special case of a two dimensional C-GARD, in which the autocatalytic values in the β matrix are greater than 0 and the cross catalytic values are smaller than 0. An advantage of GARD is its generality, having less restrictive assumptions.
Furthermore, the SVR model constitutes a means of estimating the true PFM similarity of two TFs, even if their DNA binding profiles are both unknown.
This model constitutes an effective binary representation where each nucleotide base is directly coded by two bits.
This integrated model constitutes a new war-labor paradigm.
constituted two occurrences.
Patients constitute two cohorts.
