Tests of model compounds show these to be compatible with the goal of ALK, MET, and EGFR polypharmacology.
Ferrocene, TCNQ and Ru bipy 32+ have been selected as model compounds because these are molecules with well defined redox processes.
Four biologically relevant reactive aldehydes (ACR, MDA, HNE, and ONE) were selected as model compounds for these studies, and ICD involved conversion to hydrazones with unlabeled ("light") and various heavy (d3-, N4-, N4-, or C6-) labeled DNPH.
Bisperoxidovanadium (bpV, also: bisperoxovanadium) complexes inhibit PTEN activity and serve as model compounds to study these implications.[ 12– 16] The precise mode of action of bpV inhibitors is under debate,[ 13, 16] and its elucidation can support further optimization campaigns.
Plots of most of these model compounds are available in Additional File 3.
Irreversible reaction exotherms around 350°C were observed in these model compounds using differential scanning calorimetry.
These model compounds included urea, 1,3-dimethylurea, 1,3-dimethylcarbamate, diethyl ether, methyl acetate and ethyl alcohol.
These model compounds were also used to study the influence of the acetoxy group orientation on the thermal stability and photoluminescence behavior of the polymers.
Results obtained from the use of these model compounds suggested that the backbone carbonate bond is hydrolyzed at a faster rate than the pendent chain ester bond.
The X-ray analysis of one of these model compounds was performed and its crystal structure is described/compared to that of sildenafil.
