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Determination of O-glycosylation sites in glycopeptides was developed by using two model compounds designed from mucin2 tandem repeat motif and erythropoietin.
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Three model compounds were designed and synthesized.
In order to study the degradation mechanism of these polycarbonates in more detail, a series of small model compounds were designed that mimic the repeat unit of the polymer.
Within the sphere of cancer, a number of important new commercialized drugs have been obtained from natural sources, by structural modification of natural compounds, or by the synthesis of new compounds, designed following a natural compound as model [ 8].
Recent progress in in vitro synthesis and insights into multiple antibiotic mechanisms combined in a single molecule make lantibiotics attractive model compounds for design of novel antiinfective drugs.
We evaluated the feasibility, distribution, and effects of intracoronary transfer of the human tPA (htPA) gene in a rabbit heterotopic cardiac transplant model, using a novel cationic liposome compound designed for improved delivery to vascular endothelium.
Similar results were noted for a related series of oligomeric model compounds that were specifically designed to mimic local monomer sequences present within the larger polyester structures.
These molecules were designed as model compounds for the study of chemisorption of rigid molecules containing multiple ethenyl groups on hydrogen-terminated silicon surfaces.
It is argued that silicon oxycarbide amorphous ceramics may consequently serve as model compounds for developing rational design concepts for advanced bioactive glasses.
The work comprises the optimisation of the CE separation and the ESI-MS parameters for improved sensitivity with model compounds using two successive designs of experiments.
Some polycyclic aromatic hydrocarbons (PAHs) were selected as model compounds for evaluating performance of the designed SPME fiber.
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