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Each model compartment was assumed to be homogeneous and time-invariant, thus, seasonal effects (e.g., temperature changes affecting partitioning and degradation rates) and site-to-site differences (e.g., local differences in degradation rates and sources) were not represented.

Transitions between model compartments were identical for individuals in the healthy or chronic condition states, but probabilities of experiencing severe clinical outcomes were different.

Given the best model for the population dynamics, two additional model compartments were added to account for the transmission of H5N1.

Hence, in this model, the neural compartment is not impacted by the neurotransmitter concentrations in the extracellular space.

In this model, the endosomal compartment is divided in a vacuolar part and a tubular extension, the TEN.

In our model, the 'Other' compartment is where elimination of exogenous and endogenous chemicals and proteins occur.

A minimal-PBPK model including three compartments was chosen for oxycodone: central, liver, and gut compartments.

In the restricted model four compartments are considered: plasma leucine (1), intra-hepatic leucine (2), and two plasma protein pools (3 and 4).

The fluxes into and out of each compartment are modeled by corresponding transfer rates [12].

In particular, the growth term of the proliferative cell compartment is modeled using a logistic term.

In all models, several compartments were considered.