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Table 1 shows a model combining clinical data and experimental evidence.
Nijhuis et al. used a risk assessment model combining clinical parameters and plasma interleukin 8 levels to define 3 risk groups among outpatients with febrile neutropenia (children and adults).
One study from Singapore where dengue was found all year round reported that a model combining clinical feature (skin rash) and laboratory parameters (white cell count, hemoglobin, PT, creatinine, and bilirubin levels) was able to distinguish dengue illness (mainly DF) from other infections with a sensitivity of 84% and specificity of 85% [ 29].
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This study aims to examine the accuracy of clinical prognostic predictions and to devise prediction models combining clinical variables and clinicians' prognosis for a geriatric patient sample.
Comparatively, the median was 0.63 with a 95% CI of 0.52 to 0.73 for clinical models, while those for models combining clinical and gene expression results gave a median of 0.65 with 95% CI of 0.54 to 0.74.
Further PLS-DA were performed on models combining clinical variables collected at the doctor visit with FibroDetect questions or using weighted scores; this did not substantially increase the ability of the model to discriminate between ACR + and ACR − patients.
To do so, we compared AUCs of a logistic regression model of the clinical score by itself versus the AUCs of a model combining the clinical score plus the PCT change.
These results demonstrate the feasibility of constructing a precise prognostic model combining multiple clinical, pathologic, and demographic factors.
A prediction model combining baseline clinical and psychosocial risk factors predicted patients with low, intermediate and high risk for unsuccessful return to work, both initially and at 1-year.
It is important to develop a prognostic stratification model which combines clinical, pathological and demographic factors for individualized clinical decision making.
Combining clinical studies with computational modelling can be a powerful tool to establish tsDCS protocols for specific therapeutic purposes.
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